Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.

Details

Serval ID
serval:BIB_B22BBED5F512
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
Journal
World Journal of Surgery
Author(s)
Grass F., Schäfer M., Cristaudi A., Berutto C., Aubert J.D., Gonzalez M., Demartines N., Ris H.B., Soccal P.M., Krueger T.
ISSN
1432-2323 (Electronic)
ISSN-L
0364-2313
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
39
Number
9
Pages
2274-2281
Language
english
Abstract
BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences and impact of GI complications after lung transplantation and aimed to identify risk factors.
METHODS: Retrospective analysis of all 227 consecutively performed single- and double-lung transplantations at the University hospitals of Lausanne and Geneva was performed between January 1993 and December 2010. Logistic regressions were used to test the effect of potentially influencing variables on the binary outcomes overall, severe, and surgery-requiring complications, followed by a multiple logistic regression model.
RESULTS: Final analysis included 205 patients for the purpose of the present study, and 22 patients were excluded due to re-transplantation, multiorgan transplantation, or incomplete datasets. GI complications were observed in 127 patients (62 %). Gastro-esophageal reflux disease was the most commonly observed complication (22.9 %), followed by inflammatory or infectious colitis (20.5 %) and gastroparesis (10.7 %). Major GI complications (Dindo/Clavien III-V) were observed in 83 (40.5 %) patients and were fatal in 4 patients (2.0 %). Multivariate analysis identified double-lung transplantation (p = 0.012) and early (1993-1998) transplantation period (p = 0.008) as independent risk factors for developing major GI complications. Forty-three (21 %) patients required surgery such as colectomy, cholecystectomy, and fundoplication in 6.8, 6.3, and 3.9 % of the patients, respectively. Multivariate analysis identified Charlson comorbidity index of ≥3 as an independent risk factor for developing GI complications requiring surgery (p = 0.015).
CONCLUSION: GI complications after lung transplantation are common. Outcome was rather encouraging in the setting of our transplant center.
Pubmed
Web of science
Create date
07/09/2015 15:18
Last modification date
20/08/2019 16:20
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