Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid

Détails

ID Serval
serval:BIB_B15DA500E2B1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid
Périodique
Lancet
Auteur(s)
Baumgartner  J. D., Glauser  M. P., McCutchan  J. A., Ziegler  E. J., van Melle  G., Klauber  M. R., Vogt  M., Muehlen  E., Luethy  R., Chiolero  R., Geroulanos  S.
ISSN
0140-6736
Statut éditorial
Publié
Date de publication
07/1985
Peer-reviewed
Oui
Volume
2
Numéro
8446
Pages
59-63
Notes
Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 13
Résumé
The prophylactic effect of antibody to endotoxin core glycolipid was studied in surgical patients at high risk of gram-negative infection. At randomisation (on admission to intensive care unit), every 5 days thereafter, and at onset of septic shock, patients received plasma taken from donors before (control) or after immunisation with Escherichia coli J5, a mutant with only core determinants in its endotoxin. Gram-negative shock occurred in 15 of 136 controls and 6 of 126 J5 antibody recipients and related deaths in 9 of 136 and 2 of 126, respectively. J5 antibody was most effective in abdominal surgery patients, in whom shock occurred in 13 of 83 controls and 2 of 71 antibody recipients. Although antibody prophylaxis did not lower the infection rate, it prevented the serious consequences of gram-negative infections and thus improved the overall prognosis.
Mots-clé
Bacterial Infections/epidemiology *Bacterial Vaccines Clinical Trials as Topic Double-Blind Method Endotoxins/*immunology Escherichia coli Vaccines Female Glycolipids/*immunology Gram-Negative Bacteria/immunology Humans Male Middle Aged Mycoses/epidemiology Postoperative Complications/prevention & control Random Allocation Shock, Septic/epidemiology/etiology/mortality/*prevention & control
Pubmed
Web of science
Création de la notice
19/01/2008 18:12
Dernière modification de la notice
20/08/2019 15:20
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