Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid
Details
Serval ID
serval:BIB_B15DA500E2B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid
Journal
Lancet
ISSN
0140-6736
Publication state
Published
Issued date
07/1985
Peer-reviewed
Oui
Volume
2
Number
8446
Pages
59-63
Notes
Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 13
Abstract
The prophylactic effect of antibody to endotoxin core glycolipid was studied in surgical patients at high risk of gram-negative infection. At randomisation (on admission to intensive care unit), every 5 days thereafter, and at onset of septic shock, patients received plasma taken from donors before (control) or after immunisation with Escherichia coli J5, a mutant with only core determinants in its endotoxin. Gram-negative shock occurred in 15 of 136 controls and 6 of 126 J5 antibody recipients and related deaths in 9 of 136 and 2 of 126, respectively. J5 antibody was most effective in abdominal surgery patients, in whom shock occurred in 13 of 83 controls and 2 of 71 antibody recipients. Although antibody prophylaxis did not lower the infection rate, it prevented the serious consequences of gram-negative infections and thus improved the overall prognosis.
Keywords
Bacterial Infections/epidemiology *Bacterial Vaccines Clinical Trials as Topic Double-Blind Method Endotoxins/*immunology Escherichia coli Vaccines Female Glycolipids/*immunology Gram-Negative Bacteria/immunology Humans Male Middle Aged Mycoses/epidemiology Postoperative Complications/prevention & control Random Allocation Shock, Septic/epidemiology/etiology/mortality/*prevention & control
Pubmed
Web of science
Create date
19/01/2008 18:12
Last modification date
20/08/2019 15:20