Blood virosphere in febrile Tanzanian children.

Détails

ID Serval
serval:BIB_B0B6B061E9F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blood virosphere in febrile Tanzanian children.
Périodique
Emerging microbes & infections
Auteur(s)
Cordey S., Laubscher F., Hartley M.A., Junier T., Keitel K., Docquier M., Guex N., Iseli C., Vieille G., Le Mercier P., Gleizes A., Samaka J., Mlaganile T., Kagoro F., Masimba J., Said Z., Temba H., Elbanna G.H., Tapparel C., Zanella M.C., Xenarios I., Fellay J., D'Acremont V., Kaiser L.
ISSN
2222-1751 (Electronic)
ISSN-L
2222-1751
Statut éditorial
Publié
Date de publication
12/2021
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
982-993
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An in-depth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children. Metagenomic next-generation sequencing is a powerful tool for such broad investigations, allowing the detection of RNA and DNA viral genomes. Here, we describe the blood virome of 816 febrile children (<5 years) presenting at outpatient departments in Dar es Salaam over one-year. We show that half of the patients (394/816) had at least one detected virus recognized as causes of human infection/disease (13.8% enteroviruses (enterovirus A, B, C, and rhinovirus A and C), 12% rotaviruses, 11% human herpesvirus type 6). Additionally, we report the detection of a large number of viruses (related to arthropod, vertebrate or mammalian viral species) not yet known to cause human infection/disease, highlighting those who should be on the radar, deserve specific attention in the febrile paediatric population and, more broadly, for surveillance of emerging pathogens.Trial registration: ClinicalTrials.gov identifier: NCT02225769.
Mots-clé
Blood virome, children, fever, metagenomic next-generation sequencing, virosphere
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/05/2021 8:30
Dernière modification de la notice
16/11/2021 6:38
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