Blood virosphere in febrile Tanzanian children.

Details

Serval ID
serval:BIB_B0B6B061E9F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood virosphere in febrile Tanzanian children.
Journal
Emerging microbes & infections
Author(s)
Cordey S., Laubscher F., Hartley M.A., Junier T., Keitel K., Docquier M., Guex N., Iseli C., Vieille G., Le Mercier P., Gleizes A., Samaka J., Mlaganile T., Kagoro F., Masimba J., Said Z., Temba H., Elbanna G.H., Tapparel C., Zanella M.C., Xenarios I., Fellay J., D'Acremont V., Kaiser L.
ISSN
2222-1751 (Electronic)
ISSN-L
2222-1751
Publication state
Published
Issued date
12/2021
Peer-reviewed
Oui
Volume
10
Number
1
Pages
982-993
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An in-depth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children. Metagenomic next-generation sequencing is a powerful tool for such broad investigations, allowing the detection of RNA and DNA viral genomes. Here, we describe the blood virome of 816 febrile children (<5 years) presenting at outpatient departments in Dar es Salaam over one-year. We show that half of the patients (394/816) had at least one detected virus recognized as causes of human infection/disease (13.8% enteroviruses (enterovirus A, B, C, and rhinovirus A and C), 12% rotaviruses, 11% human herpesvirus type 6). Additionally, we report the detection of a large number of viruses (related to arthropod, vertebrate or mammalian viral species) not yet known to cause human infection/disease, highlighting those who should be on the radar, deserve specific attention in the febrile paediatric population and, more broadly, for surveillance of emerging pathogens.Trial registration: ClinicalTrials.gov identifier: NCT02225769.
Keywords
Blood virome, children, fever, metagenomic next-generation sequencing, virosphere
Pubmed
Web of science
Open Access
Yes
Create date
05/05/2021 9:30
Last modification date
12/06/2021 6:33
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