Male-pattern baldness susceptibility locus at 20p11.

Détails

Ressource 1Télécharger: 5_18849991_Postprint.pdf (702.46 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_AFB4769B6AAE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
Male-pattern baldness susceptibility locus at 20p11.
Périodique
Nature Genetics
Auteur⸱e⸱s
Richards J.B., Yuan X., Geller F., Waterworth D., Bataille V., Glass D., Song K., Waeber G., Vollenweider P., Aben K.K., Kiemeney L.A., Walters B., Soranzo N., Thorsteinsdottir U., Kong A., Rafnar T., Deloukas P., Sulem P., Stefansson H., Stefansson K., Spector T.D., Mooser V.
ISSN
1546-1718
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
40
Numéro
11
Pages
1282-1284
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
Mots-clé
Alopecia, Chromosomes, Human, Pair 20, Female, Genetic Predisposition to Disease, Genome, Human, Humans, Male, Polymorphism, Single Nucleotide
URN
urn:nbn:ch:serval-BIB_AFB4769B6AAE2
OAI-PMH
oai:serval.unil.ch:BIB_AFB4769B6AAE
DOI
10.1038/ng.255
Pubmed
18849991
Web of science
000260501500017
Open Access
Oui
Création de la notice
17/11/2008 9:57
Dernière modification de la notice
20/08/2019 16:19
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