New insights into the role of PPARs.

Détails

ID Serval
serval:BIB_AD83D596CCB8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
New insights into the role of PPARs.
Périodique
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Auteur⸱e⸱s
Montagner A., Rando G., Degueurce G., Leuenberger N., Michalik L., Wahli W.
ISSN
1532-2823 (Electronic)
ISSN-L
0952-3278
Statut éditorial
Publié
Date de publication
2011
Volume
85
Numéro
5
Pages
235-243
Langue
anglais
Résumé
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors belonging to the nuclear hormone receptor family. While PPARs are best known as regulators of energy homeostasis, evidence also has accumulated recently for their involvement in basic cellular functions. We review novel insights into PPAR functions in skin wound healing and liver, with emphasis on PPARβ/δ and PPARα, respectively. Activation of PPARβ/δ expression in response to injury promotes keratinocyte survival, directional sensing, and migration over the wound bed. In addition, interleukin (IL)-1 produced by the keratinocytes activates PPARβ/δ expression in the underlying fibroblasts, which hinders the mitotic activity of keratinocytes via inhibition of IL-1 signaling. Initially, roles were identified for PPARα in fatty acid catabolism. However, PPARα is also involved in downregulating many genes in female mammals. We have elucidated the mechanism of this repression, which requires sumoylation of PPARα. Physiologically, this control confers protection against estrogen-induced intrahepatic cholestasis.
Mots-clé
Animals, Cholestasis, Intrahepatic/etiology, Cholestasis, Intrahepatic/metabolism, Energy Metabolism, Estrogens/metabolism, Fatty Acids/metabolism, Female, Humans, Interleukin-1/metabolism, Keratinocytes/metabolism, Keratinocytes/pathology, Liver/metabolism, Male, Peroxisome Proliferator-Activated Receptors/metabolism, Sex Characteristics, Signal Transduction, Skin/metabolism, Skin/pathology, Wound Healing
Pubmed
Web of science
Création de la notice
15/08/2011 10:15
Dernière modification de la notice
20/08/2019 16:17
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