New insights into the role of PPARs.

Details

Serval ID
serval:BIB_AD83D596CCB8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
New insights into the role of PPARs.
Journal
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Author(s)
Montagner A., Rando G., Degueurce G., Leuenberger N., Michalik L., Wahli W.
ISSN
1532-2823 (Electronic)
ISSN-L
0952-3278
Publication state
Published
Issued date
2011
Volume
85
Number
5
Pages
235-243
Language
english
Abstract
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors belonging to the nuclear hormone receptor family. While PPARs are best known as regulators of energy homeostasis, evidence also has accumulated recently for their involvement in basic cellular functions. We review novel insights into PPAR functions in skin wound healing and liver, with emphasis on PPARβ/δ and PPARα, respectively. Activation of PPARβ/δ expression in response to injury promotes keratinocyte survival, directional sensing, and migration over the wound bed. In addition, interleukin (IL)-1 produced by the keratinocytes activates PPARβ/δ expression in the underlying fibroblasts, which hinders the mitotic activity of keratinocytes via inhibition of IL-1 signaling. Initially, roles were identified for PPARα in fatty acid catabolism. However, PPARα is also involved in downregulating many genes in female mammals. We have elucidated the mechanism of this repression, which requires sumoylation of PPARα. Physiologically, this control confers protection against estrogen-induced intrahepatic cholestasis.
Keywords
Animals, Cholestasis, Intrahepatic/etiology, Cholestasis, Intrahepatic/metabolism, Energy Metabolism, Estrogens/metabolism, Fatty Acids/metabolism, Female, Humans, Interleukin-1/metabolism, Keratinocytes/metabolism, Keratinocytes/pathology, Liver/metabolism, Male, Peroxisome Proliferator-Activated Receptors/metabolism, Sex Characteristics, Signal Transduction, Skin/metabolism, Skin/pathology, Wound Healing
Pubmed
Web of science
Create date
15/08/2011 10:15
Last modification date
20/08/2019 16:17
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