Correlation of prostaglandin-induced mitochondrial calcium release with contraction in bovine intrapulmonary vein

Détails

ID Serval
serval:BIB_ACF25982A874
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Correlation of prostaglandin-induced mitochondrial calcium release with contraction in bovine intrapulmonary vein
Périodique
Prostaglandins
Auteur(s)
McNamara  D. B., Roulet  M. J., Gruetter  C. A., Hyman  A. L., Kadowitz  P. J.
ISSN
0090-6980 (Print)
Statut éditorial
Publié
Date de publication
08/1980
Volume
20
Numéro
2
Pages
311-20
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
The effects of prostaglandins A2, A1, F2 alpha, E2, E2, F1 beta and an analog of PGH2 upon calcium release from mitochondria isolated from bovine intrapulmonary vein and contraction of helical strips of the same tissue were determined. The order of activity of the prostaglandins for calcium release was similar to that for contraction with the exception of the PGH2 analog. It is suggested that prostaglandin A2, F2 alpha, E2 and A1 induced release of mitochondrial calcium may influence the contractile state of bovine intrapulmonary vein. However, the PGH2 analog has a subcellular mechanism other than or in addition to mitochondrial calcium release and is different from the other prostaglandins.
Mots-clé
Animals Cattle Female Mitochondria/metabolism Muscle Contraction/drug effects Muscle, Smooth, Vascular/*physiology Prostaglandin Endoperoxides, Synthetic/pharmacology Prostaglandins/*pharmacology Prostaglandins A/pharmacology Prostaglandins E/pharmacology Prostaglandins F/pharmacology Prostaglandins H/pharmacology Pulmonary Veins/physiology Structure-Activity Relationship
Pubmed
Web of science
Création de la notice
24/01/2008 21:33
Dernière modification de la notice
20/08/2019 16:16
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