Correlation of prostaglandin-induced mitochondrial calcium release with contraction in bovine intrapulmonary vein
Details
Serval ID
serval:BIB_ACF25982A874
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Correlation of prostaglandin-induced mitochondrial calcium release with contraction in bovine intrapulmonary vein
Journal
Prostaglandins
ISSN
0090-6980 (Print)
Publication state
Published
Issued date
08/1980
Volume
20
Number
2
Pages
311-20
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
The effects of prostaglandins A2, A1, F2 alpha, E2, E2, F1 beta and an analog of PGH2 upon calcium release from mitochondria isolated from bovine intrapulmonary vein and contraction of helical strips of the same tissue were determined. The order of activity of the prostaglandins for calcium release was similar to that for contraction with the exception of the PGH2 analog. It is suggested that prostaglandin A2, F2 alpha, E2 and A1 induced release of mitochondrial calcium may influence the contractile state of bovine intrapulmonary vein. However, the PGH2 analog has a subcellular mechanism other than or in addition to mitochondrial calcium release and is different from the other prostaglandins.
Keywords
Animals
Cattle
Female
Mitochondria/metabolism
Muscle Contraction/drug effects
Muscle, Smooth, Vascular/*physiology
Prostaglandin Endoperoxides, Synthetic/pharmacology
Prostaglandins/*pharmacology
Prostaglandins A/pharmacology
Prostaglandins E/pharmacology
Prostaglandins F/pharmacology
Prostaglandins H/pharmacology
Pulmonary Veins/physiology
Structure-Activity Relationship
Pubmed
Web of science
Create date
24/01/2008 21:33
Last modification date
20/08/2019 16:16
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