Inhibition of Na(+)-K(+)-ATPase by digoxin and its relation with energy expenditure and nutrient oxidation rate.

Détails

ID Serval
serval:BIB_ACB0AF2F373D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inhibition of Na(+)-K(+)-ATPase by digoxin and its relation with energy expenditure and nutrient oxidation rate.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur⸱e⸱s
Lyon X., Schutz Y., Buclin T., Jéquier E., Dériaz O.
ISSN
0193-1849 (Print)
ISSN-L
0002-9513
Statut éditorial
Publié
Date de publication
1995
Volume
268
Numéro
6 Pt 1
Pages
E1051-E1056
Langue
anglais
Résumé
This study investigates the effects of digoxin, an inhibitor of the Na+ pump (Na(+)-K(+)-ATPase), on resting metabolic rate (RMR), respiratory quotient (RQ), and nutrient oxidation rate. Twelve healthy male subjects followed a double-blind protocol design and received either 1 mg/day digoxin or a placebo 2 days before indirect calorimetry measurements. Digoxin induced a 0.22 +/- 0.07 kJ/min or 3.8 +/- 1.5% (mean +/- SE, P = 0.01) decrease in RMR and a 0.40 +/- 0.13 kJ/min (P = 0.01) decrease in fat oxidation rate, whereas carbohydrate and protein oxidation rates did not change significantly. A dose-response relationship between serum digoxin and RQ was observed. These results suggest that digoxin reduces not only RMR but also fat oxidation rate by mechanisms that remain to be elucidated. Because a linkage and an association between genes coding the Na(+)-K(+)-ATPase and the RQ have been previously observed, the present demonstration of an effect of Na(+)-K(+)-ATPase inhibition on fat oxidation rate strengthens the concept that the activity of this enzyme may play a role in body weight regulation.
Mots-clé
Adult, Basal Metabolism/drug effects, Blood Glucose/metabolism, Blood Pressure/drug effects, Calorimetry, Digoxin/pharmacokinetics, Digoxin/pharmacology, Energy Metabolism/drug effects, Fatty Acids, Nonesterified/blood, Heart Rate/drug effects, Humans, Insulin/blood, Lactates/metabolism, Male, Oxygen Consumption/drug effects, Potassium/blood, Reference Values, Regression Analysis, Sodium/blood, Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors
Pubmed
Web of science
Création de la notice
21/01/2008 13:09
Dernière modification de la notice
20/08/2019 15:16
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