Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.
Détails
ID Serval
serval:BIB_AC7C98A91446
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.
Périodique
Head & neck
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Statut éditorial
Publié
Date de publication
09/2016
Peer-reviewed
Oui
Volume
38
Numéro
9
Pages
1407-1415
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The use of lymphatic vessel density as a predictor of occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported.
Staining of the specific lymphatic endothelial cells nuclear marker, PROX1, as an indicator of lymphatic vessel density was determined by counting the number of positive cells in squamous cell carcinomas (SCCs) of the oral cavity and the oropharynx with clinically negative necks. Correlation with histopathological data was established.
Peritumoral PROX1 lymphatic nuclear count significantly correlated with the detection of OLNM in multivariate analysis (p < .005). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this parameter was 60%, 95%, 85%, and 90%, respectively.
Peritumoral PROX1 lymphatic nuclear count in primary SCCs of the oral cavity and the oropharynx allows accurate prediction of occult lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1407-1415, 2016.
Staining of the specific lymphatic endothelial cells nuclear marker, PROX1, as an indicator of lymphatic vessel density was determined by counting the number of positive cells in squamous cell carcinomas (SCCs) of the oral cavity and the oropharynx with clinically negative necks. Correlation with histopathological data was established.
Peritumoral PROX1 lymphatic nuclear count significantly correlated with the detection of OLNM in multivariate analysis (p < .005). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this parameter was 60%, 95%, 85%, and 90%, respectively.
Peritumoral PROX1 lymphatic nuclear count in primary SCCs of the oral cavity and the oropharynx allows accurate prediction of occult lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1407-1415, 2016.
Mots-clé
Aged, Analysis of Variance, Biomarkers, Tumor/metabolism, Carcinoma, Squamous Cell/pathology, Cohort Studies, Female, Head and Neck Neoplasms/pathology, Homeodomain Proteins/metabolism, Humans, Immunohistochemistry, Lymph Nodes/pathology, Lymphatic Metastasis/pathology, Lymphatic Vessels/pathology, Male, Middle Aged, Mouth/pathology, Mouth Neoplasms/pathology, Multivariate Analysis, Neoplasm Invasiveness/pathology, Neoplasm Staging, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Assessment, Switzerland, Tumor Suppressor Proteins/metabolism, PROX1, microvascular lymphatic density, occult lymph node metastasis, oral squamous cell carcinoma, prognosis
Pubmed
Web of science
Création de la notice
11/04/2016 14:04
Dernière modification de la notice
07/09/2021 5:36
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