Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.

Details

Serval ID
serval:BIB_AC7C98A91446
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.
Journal
Head & neck
Author(s)
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y.
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
38
Number
9
Pages
1407-1415
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The use of lymphatic vessel density as a predictor of occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported.
Staining of the specific lymphatic endothelial cells nuclear marker, PROX1, as an indicator of lymphatic vessel density was determined by counting the number of positive cells in squamous cell carcinomas (SCCs) of the oral cavity and the oropharynx with clinically negative necks. Correlation with histopathological data was established.
Peritumoral PROX1 lymphatic nuclear count significantly correlated with the detection of OLNM in multivariate analysis (p < .005). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this parameter was 60%, 95%, 85%, and 90%, respectively.
Peritumoral PROX1 lymphatic nuclear count in primary SCCs of the oral cavity and the oropharynx allows accurate prediction of occult lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1407-1415, 2016.

Keywords
Aged, Analysis of Variance, Biomarkers, Tumor/metabolism, Carcinoma, Squamous Cell/pathology, Cohort Studies, Female, Head and Neck Neoplasms/pathology, Homeodomain Proteins/metabolism, Humans, Immunohistochemistry, Lymph Nodes/pathology, Lymphatic Metastasis/pathology, Lymphatic Vessels/pathology, Male, Middle Aged, Mouth/pathology, Mouth Neoplasms/pathology, Multivariate Analysis, Neoplasm Invasiveness/pathology, Neoplasm Staging, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Assessment, Switzerland, Tumor Suppressor Proteins/metabolism, PROX1, microvascular lymphatic density, occult lymph node metastasis, oral squamous cell carcinoma, prognosis
Pubmed
Web of science
Create date
11/04/2016 15:04
Last modification date
20/08/2019 16:16
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