Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.
Détails
ID Serval
serval:BIB_ABB84FAF5874
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.
Périodique
Annals of Neurology
ISSN
0364-5134
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
56
Numéro
6
Pages
905-908
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Résumé
Hypocretin/orexin deficiency appears to be a consistent feature of narcolepsy with a putative autoimmune mechanism involved. We treated four hypocretin/orexin-deficient narcolepsy patients with intravenous immunoglobulins and assessed the efficacy by repeated polysomnographies and questionnaires. Three patients received the treatment within a few months after acute onset of narcolepsy. A clear improvement in the frequency and severity of cataplexy was obtained with a benefic effect up to 7 months without any anticataplectics drugs at follow-up. Our findings point to the importance of early diagnosis of narcolepsy, which once treated quickly may modify its long-term outlook.
Mots-clé
Adult, Cataplexy/diagnosis, Cataplexy/drug therapy, Child, Disease Management, Drug Administration Schedule, Female, Humans, Immunoglobulins, Intravenous/therapeutic use, Male, Middle Aged, Narcolepsy/diagnosis, Narcolepsy/drug therapy, Time Factors
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
20/08/2019 16:15