Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.
Details
Serval ID
serval:BIB_ABB84FAF5874
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.
Journal
Annals of Neurology
ISSN
0364-5134
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
56
Number
6
Pages
905-908
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Abstract
Hypocretin/orexin deficiency appears to be a consistent feature of narcolepsy with a putative autoimmune mechanism involved. We treated four hypocretin/orexin-deficient narcolepsy patients with intravenous immunoglobulins and assessed the efficacy by repeated polysomnographies and questionnaires. Three patients received the treatment within a few months after acute onset of narcolepsy. A clear improvement in the frequency and severity of cataplexy was obtained with a benefic effect up to 7 months without any anticataplectics drugs at follow-up. Our findings point to the importance of early diagnosis of narcolepsy, which once treated quickly may modify its long-term outlook.
Keywords
Adult, Cataplexy/diagnosis, Cataplexy/drug therapy, Child, Disease Management, Drug Administration Schedule, Female, Humans, Immunoglobulins, Intravenous/therapeutic use, Male, Middle Aged, Narcolepsy/diagnosis, Narcolepsy/drug therapy, Time Factors
Pubmed
Web of science
Create date
24/01/2008 16:55
Last modification date
20/08/2019 16:15