Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Détails

Ressource 1Télécharger: Giraldi2020_Article_RiskFactorsForPancreasAndLungN.pdf (545.38 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_AA8A64DE3873
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.
Périodique
Endocrine
Auteur⸱e⸱s
Giraldi L., Vecchioni A., Carioli G., Bilotta M., La Rosa S., Imperatori A., Volante M., Brizzi M.P., Inzani F., Petrone G., Schinzari G., Bianchi A., Margaritora S., Alfieri S., La Vecchia C., Boccia S., Rindi G.
ISSN
1559-0100 (Electronic)
ISSN-L
1355-008X
Statut éditorial
Publié
Date de publication
01/2021
Peer-reviewed
Oui
Volume
71
Numéro
1
Pages
233-241
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.
We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information.
Increased risk was associated with history of cancer ("other tumor", lung OR = 7.18; 95% CI: 2.55-20.20 and pancreas OR = 5.88; 95% CI: 2.43-14.22; "family history of tumor", lung OR = 2.66; 95% CI: 1.53-4.64 and pancreas OR = 1.94; 95% CI: 1.19-3.17; "family history of lung tumor", lung OR = 2.56; 95% CI: 1.05-6.24 and pancreas OR = 2.60; 95% CI: 1.13-5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR = 3.01; 95% CI: 1.15-7.89).
Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.
Mots-clé
Case–control, Lung, Neuroendocrine neoplasia, OR, Pancreas, Risk factor
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/09/2020 13:26
Dernière modification de la notice
02/03/2021 7:26
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