Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_AA8A64DE3873
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.
Journal
Endocrine
Author(s)
Giraldi L., Vecchioni A., Carioli G., Bilotta M., La Rosa S., Imperatori A., Volante M., Brizzi M.P., Inzani F., Petrone G., Schinzari G., Bianchi A., Margaritora S., Alfieri S., La Vecchia C., Boccia S., Rindi G.
ISSN
1559-0100 (Electronic)
ISSN-L
1355-008X
Publication state
Published
Issued date
31/08/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.
We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information.
Increased risk was associated with history of cancer ("other tumor", lung OR = 7.18; 95% CI: 2.55-20.20 and pancreas OR = 5.88; 95% CI: 2.43-14.22; "family history of tumor", lung OR = 2.66; 95% CI: 1.53-4.64 and pancreas OR = 1.94; 95% CI: 1.19-3.17; "family history of lung tumor", lung OR = 2.56; 95% CI: 1.05-6.24 and pancreas OR = 2.60; 95% CI: 1.13-5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR = 3.01; 95% CI: 1.15-7.89).
Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.
Keywords
Case–control, Lung, Neuroendocrine neoplasia, OR, Pancreas, Risk factor
Pubmed
Web of science
Open Access
Yes
Create date
04/09/2020 12:26
Last modification date
07/11/2020 6:20
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