From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.

Détails

ID Serval
serval:BIB_AA453CC39FA7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.
Périodique
Nutrients
Auteur⸱e⸱s
Romani M., Berger M.M., D'Amelio P.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Statut éditorial
Publié
Date de publication
22/01/2022
Peer-reviewed
Oui
Volume
14
Numéro
3
Pages
483
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
With extended life expectancy, the older population is constantly increasing, and consequently, so too is the prevalence of age-related disorders. Sarcopenia, the pathological age-related loss of muscle mass and function; and malnutrition, the imbalance in nutrient intake and resultant energy production, are both commonly occurring conditions in old adults. Altered nutrition plays a crucial role in the onset of sarcopenia, and both these disorders are associated with detrimental consequences for patients (e.g., frailty, morbidity, and mortality) and society (e.g., healthcare costs). Importantly, sarcopenia and malnutrition also share critical molecular alterations, such as mitochondrial dysfunction, increased oxidative stress, and a chronic state of low grade and sterile inflammation, defined as inflammageing. Given the connection between malnutrition and sarcopenia, nutritional interventions capable of affecting mitochondrial health and correcting inflammageing are emerging as possible strategies to target sarcopenia. Here, we discuss mitochondrial dysfunction, oxidative stress, and inflammageing as key features leading to sarcopenia. Moreover, we examine the effects of some branched amino acids, omega-3 PUFA, and selected micronutrients on these pathways, and their potential role in modulating sarcopenia, warranting further clinical investigation.
Mots-clé
Amino Acids, Frailty, Humans, Micronutrients, Mitochondria/metabolism, Sarcopenia, branched-chain amino acids (BCAAs), inflammageing, malnutrition, mitochondria, n-3 PUFA, sarcopenia, selenium, senescence, vitamin D, zinc
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/02/2022 17:49
Dernière modification de la notice
22/03/2022 7:34
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