From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.

Details

Serval ID
serval:BIB_AA453CC39FA7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.
Journal
Nutrients
Author(s)
Romani M., Berger M.M., D'Amelio P.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
22/01/2022
Peer-reviewed
Oui
Volume
14
Number
3
Pages
483
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
With extended life expectancy, the older population is constantly increasing, and consequently, so too is the prevalence of age-related disorders. Sarcopenia, the pathological age-related loss of muscle mass and function; and malnutrition, the imbalance in nutrient intake and resultant energy production, are both commonly occurring conditions in old adults. Altered nutrition plays a crucial role in the onset of sarcopenia, and both these disorders are associated with detrimental consequences for patients (e.g., frailty, morbidity, and mortality) and society (e.g., healthcare costs). Importantly, sarcopenia and malnutrition also share critical molecular alterations, such as mitochondrial dysfunction, increased oxidative stress, and a chronic state of low grade and sterile inflammation, defined as inflammageing. Given the connection between malnutrition and sarcopenia, nutritional interventions capable of affecting mitochondrial health and correcting inflammageing are emerging as possible strategies to target sarcopenia. Here, we discuss mitochondrial dysfunction, oxidative stress, and inflammageing as key features leading to sarcopenia. Moreover, we examine the effects of some branched amino acids, omega-3 PUFA, and selected micronutrients on these pathways, and their potential role in modulating sarcopenia, warranting further clinical investigation.
Keywords
Amino Acids, Frailty, Humans, Micronutrients, Mitochondria/metabolism, Sarcopenia, branched-chain amino acids (BCAAs), inflammageing, malnutrition, mitochondria, n-3 PUFA, sarcopenia, selenium, senescence, vitamin D, zinc
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2022 17:49
Last modification date
22/03/2022 7:34
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