Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.
Détails
Etat: Public
Version: Final published version
ID Serval
serval:BIB_A8A26B222239
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.
Périodique
Neuroscience
ISSN
1873-7544 (Electronic)
ISSN-L
0306-4522
Statut éditorial
Publié
Date de publication
26/05/2016
Peer-reviewed
Oui
Volume
323
Pages
135-156
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Under a Creative Commons license
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Under a Creative Commons license
Résumé
Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under the term "neurometabolic coupling" (NMC). In this review we describe these mechanisms of coupling and how they involve astrocytes. From a physiological point of view, these mechanisms of coupling are particularly important to ensure normal synaptic functioning when neurons undergo rapid and repetitive changes in the firing rate such as during the sleep/wake transitions. Investigations into brain energy metabolism during the sleep/wake cycle have been mainly focused on glucose (Gluc) consumption and on glycogen metabolism. However, the recent development of substrate-specific biosensors allowed measurements of the variation in extracellular levels of glutamate, Gluc and lactate (Lac) with a time resolution compatible with sleep stage duration. Together with gene expression data these experiments allowed to better define the variations of energy metabolite regulation across the sleep/wake cycle. The aim of this review is to bring into perspective the role of astrocytes and NMC in the regulation of the sleep/wake cycle. The data reviewed also suggest an important role of the astrocytic network. In addition, the role of astrocytes in NMC mechanisms is consistent with the "local and use dependent" sleep hypothesis.
Mots-clé
Animals, Astrocytes/metabolism, Humans, Neurons/metabolism, Sleep/physiology, Wakefulness/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/01/2016 14:55
Dernière modification de la notice
16/02/2021 7:27