Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.

Details

Ressource 1Download: 26704637.pdf (1529.34 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_A8A26B222239
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.
Journal
Neuroscience
Author(s)
Petit J.M., Magistretti P.J.
ISSN
1873-7544 (Electronic)
ISSN-L
0306-4522
Publication state
Published
Issued date
26/05/2016
Peer-reviewed
Oui
Volume
323
Pages
135-156
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Under a Creative Commons license

Abstract
Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under the term "neurometabolic coupling" (NMC). In this review we describe these mechanisms of coupling and how they involve astrocytes. From a physiological point of view, these mechanisms of coupling are particularly important to ensure normal synaptic functioning when neurons undergo rapid and repetitive changes in the firing rate such as during the sleep/wake transitions. Investigations into brain energy metabolism during the sleep/wake cycle have been mainly focused on glucose (Gluc) consumption and on glycogen metabolism. However, the recent development of substrate-specific biosensors allowed measurements of the variation in extracellular levels of glutamate, Gluc and lactate (Lac) with a time resolution compatible with sleep stage duration. Together with gene expression data these experiments allowed to better define the variations of energy metabolite regulation across the sleep/wake cycle. The aim of this review is to bring into perspective the role of astrocytes and NMC in the regulation of the sleep/wake cycle. The data reviewed also suggest an important role of the astrocytic network. In addition, the role of astrocytes in NMC mechanisms is consistent with the "local and use dependent" sleep hypothesis.

Keywords
Animals, Astrocytes/metabolism, Humans, Neurons/metabolism, Sleep/physiology, Wakefulness/physiology
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2016 14:55
Last modification date
20/08/2019 16:13
Usage data