Inflammatory diseases: is ubiquitinated NEMO at the hub?

Détails

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ID Serval
serval:BIB_A845825978C2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
UNIL/CHUV
Titre
Inflammatory diseases: is ubiquitinated NEMO at the hub?
Périodique
Current Biology
Auteur⸱e⸱s
Burns K.A., Martinon F.
ISSN
0960-9822 (Print)
ISSN-L
0960-9822
Statut éditorial
Publié
Date de publication
2004
Volume
14
Numéro
24
Pages
R1040-R1042
Langue
anglais
Résumé
Many patients with Crohn's disease carry mutations in NOD2, a molecule that can both activate and attenuate the pro-inflammatory effects of NF-kappa B. Recent studies implicate NOD2-induced ubiquitination of the NF-kappa B regulator NEMO as a potential means of manipulating the NF-kappa B signal.
Mots-clé
Acetylmuramyl-Alanyl-Isoglutamine/metabolism, Bacteria/metabolism, Carrier Proteins/metabolism, Crohn Disease/genetics, Crohn Disease/metabolism, Humans, I-kappa B Kinase, Intracellular Signaling Peptides and Proteins/genetics, Intracellular Signaling Peptides and Proteins/metabolism, Mutation/genetics, NF-kappa B/metabolism, Nod2 Signaling Adaptor Protein, Protein Structure, Tertiary, Signal Transduction/physiology, Ubiquitin/metabolism
OAI-PMH
oai:serval.unil.ch:BIB_A845825978C2
DOI
10.1016/j.cub.2004.11.040
Pubmed
15620634
Web of science
000226069400008
Open Access
Oui
Création de la notice
21/02/2011 16:36
Dernière modification de la notice
20/08/2019 16:12
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