Inflammatory diseases: is ubiquitinated NEMO at the hub?

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Serval ID
serval:BIB_A845825978C2
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
UNIL/CHUV
Title
Inflammatory diseases: is ubiquitinated NEMO at the hub?
Journal
Current biology
Author(s)
Burns K.A., Martinon F.
ISSN
0960-9822 (Print)
ISSN-L
0960-9822
Publication state
Published
Issued date
29/12/2004
Peer-reviewed
Oui
Volume
14
Number
24
Pages
R1040-2
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Many patients with Crohn's disease carry mutations in NOD2, a molecule that can both activate and attenuate the pro-inflammatory effects of NF-kappa B. Recent studies implicate NOD2-induced ubiquitination of the NF-kappa B regulator NEMO as a potential means of manipulating the NF-kappa B signal.
Keywords
Acetylmuramyl-Alanyl-Isoglutamine/metabolism, Bacteria/metabolism, Carrier Proteins/metabolism, Crohn Disease/genetics, Crohn Disease/metabolism, Humans, I-kappa B Kinase, Intracellular Signaling Peptides and Proteins/genetics, Intracellular Signaling Peptides and Proteins/metabolism, Mutation/genetics, NF-kappa B/metabolism, Nod2 Signaling Adaptor Protein, Protein Structure, Tertiary, Signal Transduction/physiology, Ubiquitin/metabolism
OAI-PMH
oai:serval.unil.ch:BIB_A845825978C2
DOI
10.1016/j.cub.2004.11.040
Pubmed
15620634
Web of science
000226069400008
Open Access
Yes
Create date
21/02/2011 16:36
Last modification date
05/09/2024 10:00
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