KIBRA gene variants are associated with episodic memory in healthy elderly.

Détails

ID Serval
serval:BIB_A83D9E4F2373
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
KIBRA gene variants are associated with episodic memory in healthy elderly.
Périodique
Neurobiology of Aging
Auteur⸱e⸱s
Schaper K., Kolsch H., Popp J., Wagner M., Jessen F.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
29
Numéro
7
Pages
1123-1125
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an in-depth characterized sample of healthy elderly subjects. The effectsizes of the respective KIBRA SNP on memory even exceed those of the initial report. In parallel to the first study, the effect is restricted to hippocampus-related episodic memory without effects on frontal lobe function. The impact of KIBRA on memory is most likely of high relevance in elderly subjects as it is in young.
Mots-clé
Cognition/physiology, Female, Genetic Variation/genetics, Humans, Intracellular Signaling Peptides and Proteins, Male, Memory/physiology, Middle Aged, Mutation/genetics, Phosphoproteins, Polymorphism, Single Nucleotide/genetics, Proteins/genetics
Pubmed
Création de la notice
29/10/2012 11:31
Dernière modification de la notice
20/08/2019 16:12
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