KIBRA gene variants are associated with episodic memory in healthy elderly.
Details
Serval ID
serval:BIB_A83D9E4F2373
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
KIBRA gene variants are associated with episodic memory in healthy elderly.
Journal
Neurobiology of Aging
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
29
Number
7
Pages
1123-1125
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an in-depth characterized sample of healthy elderly subjects. The effectsizes of the respective KIBRA SNP on memory even exceed those of the initial report. In parallel to the first study, the effect is restricted to hippocampus-related episodic memory without effects on frontal lobe function. The impact of KIBRA on memory is most likely of high relevance in elderly subjects as it is in young.
Keywords
Cognition/physiology, Female, Genetic Variation/genetics, Humans, Intracellular Signaling Peptides and Proteins, Male, Memory/physiology, Middle Aged, Mutation/genetics, Phosphoproteins, Polymorphism, Single Nucleotide/genetics, Proteins/genetics
Pubmed
Create date
29/10/2012 10:31
Last modification date
20/08/2019 15:12
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