Tumor-host interactions: the role of inflammation.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
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ID Serval
serval:BIB_A7E45B51FDEF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Tumor-host interactions: the role of inflammation.
Périodique
Histochemistry and Cell Biology
Auteur⸱e⸱s
Le Bitoux M.A., Stamenkovic I.
ISSN
0948-6143 (Print)
ISSN-L
0948-6143
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
130
Numéro
6
Pages
1079-1090
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
It is well established that interactions between tumor cells and the host tissue stroma play a key role in determining whether and how any given solid malignancy will develop. In most cases, tumor cells hijack stromal cell functions for their own benefit and ultimately dictate the rules of engagement to the host tissue microenvironment. However, the contribution of the different stromal cell components to tumor growth remains to be clarified. Because most solid tumors are accompanied by a local inflammatory response, it has long been thought that inflammation and carcinogenesis are related. If formal proof that cancer can be initiated by inflammation in the absence of exogenous carcinogens is still lacking, there is abundant evidence that the inflammatory response can play a central role in modulating tumor growth and progression. This review will discuss some of the mechanisms whereby inflammation can both enhance and inhibit tumor growth.
Mots-clé
Animals, Chemotaxis, Leukocyte, Humans, Inflammation/immunology, Inflammation/metabolism, Inflammation Mediators/metabolism, Leukocytes/immunology, Leukocytes/metabolism, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Macrophages/immunology, Macrophages/metabolism, Neoplasm Metastasis, Neoplasms/immunology, Neoplasms/metabolism, Stromal Cells/immunology, Stromal Cells/metabolism, Tumor Escape
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/12/2008 9:40
Dernière modification de la notice
14/02/2022 7:56
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