Tumor-host interactions: the role of inflammation.

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Serval ID
serval:BIB_A7E45B51FDEF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor-host interactions: the role of inflammation.
Journal
Histochemistry and Cell Biology
Author(s)
Le Bitoux M.A., Stamenkovic I.
ISSN
0948-6143 (Print)
ISSN-L
0948-6143
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
130
Number
6
Pages
1079-1090
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
It is well established that interactions between tumor cells and the host tissue stroma play a key role in determining whether and how any given solid malignancy will develop. In most cases, tumor cells hijack stromal cell functions for their own benefit and ultimately dictate the rules of engagement to the host tissue microenvironment. However, the contribution of the different stromal cell components to tumor growth remains to be clarified. Because most solid tumors are accompanied by a local inflammatory response, it has long been thought that inflammation and carcinogenesis are related. If formal proof that cancer can be initiated by inflammation in the absence of exogenous carcinogens is still lacking, there is abundant evidence that the inflammatory response can play a central role in modulating tumor growth and progression. This review will discuss some of the mechanisms whereby inflammation can both enhance and inhibit tumor growth.
Keywords
Animals, Chemotaxis, Leukocyte, Humans, Inflammation/immunology, Inflammation/metabolism, Inflammation Mediators/metabolism, Leukocytes/immunology, Leukocytes/metabolism, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Macrophages/immunology, Macrophages/metabolism, Neoplasm Metastasis, Neoplasms/immunology, Neoplasms/metabolism, Stromal Cells/immunology, Stromal Cells/metabolism, Tumor Escape
Pubmed
Web of science
Open Access
Yes
Create date
16/12/2008 9:40
Last modification date
25/09/2019 6:10
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