Neuroprotective effects of lactate and ketone bodies in acute brain injury.
Détails
ID Serval
serval:BIB_A6B0845201E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neuroprotective effects of lactate and ketone bodies in acute brain injury.
Périodique
Journal of cerebral blood flow and metabolism
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
07/2024
Peer-reviewed
Oui
Volume
44
Numéro
7
Pages
1078-1088
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.
Mots-clé
Ketone Bodies/metabolism, Humans, Lactic Acid/metabolism, Neuroprotective Agents/therapeutic use, Animals, Brain Injuries/metabolism, Brain/metabolism, Alternative brain fuels, TBI, brain metabolism, hypoxia, ketone bodies, lactate, neuroprotection, stroke
Pubmed
Web of science
Création de la notice
15/04/2024 13:39
Dernière modification de la notice
15/06/2024 7:03