Neuroprotective effects of lactate and ketone bodies in acute brain injury.
Details
Serval ID
serval:BIB_A6B0845201E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuroprotective effects of lactate and ketone bodies in acute brain injury.
Journal
Journal of cerebral blood flow and metabolism
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
07/2024
Peer-reviewed
Oui
Volume
44
Number
7
Pages
1078-1088
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.
Keywords
Ketone Bodies/metabolism, Humans, Lactic Acid/metabolism, Neuroprotective Agents/therapeutic use, Animals, Brain Injuries/metabolism, Brain/metabolism, Alternative brain fuels, TBI, brain metabolism, hypoxia, ketone bodies, lactate, neuroprotection, stroke
Pubmed
Web of science
Create date
15/04/2024 13:39
Last modification date
15/06/2024 7:03