Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_A6249CF0D69F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.
Périodique
Oncoimmunology
Auteur(s)
de Jonge K., Tillé L., Lourenco J., Maby-El Hajjami H., Nassiri S., Racle J., Gfeller D., Delorenzi M., Verdeil G., Baumgaertner P., Speiser D.E.
ISSN
2162-402X (Electronic)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
02/02/2021
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
1873585
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.
Mots-clé
B cells, immune checkpoint, inflammation, melanoma, tumor microenvironment
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/03/2021 14:55
Dernière modification de la notice
30/04/2021 6:13
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