Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.

Details

Serval ID
serval:BIB_A6249CF0D69F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.
Journal
Oncoimmunology
Author(s)
de Jonge K., Tillé L., Lourenco J., Maby-El Hajjami H., Nassiri S., Racle J., Gfeller D., Delorenzi M., Verdeil G., Baumgaertner P., Speiser D.E.
ISSN
2162-402X (Electronic)
ISSN-L
2162-4011
Publication state
Published
Issued date
02/02/2021
Peer-reviewed
Oui
Volume
10
Number
1
Pages
1873585
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.
Keywords
B cells, immune checkpoint, inflammation, melanoma, tumor microenvironment
Pubmed
Web of science
Open Access
Yes
Create date
08/03/2021 15:55
Last modification date
15/03/2021 7:26
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