A multicentric evaluation of IDMS-traceable creatinine enzymatic assays

Détails

ID Serval
serval:BIB_A5BA45ABA839
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A multicentric evaluation of IDMS-traceable creatinine enzymatic assays
Périodique
Clin Chim Acta
Auteur(s)
Pieroni L., Delanaye P., Boutten A., Bargnoux A. S., Rozet E., Delatour V., Carlier M. C., Hanser A. M., Cavalier E., Froissart M., Cristol J. P., Societe Francaise de Biologie Clinique
ISSN
1873-3492 (Electronic))
ISSN-L
0009-8981
Statut éditorial
Publié
Date de publication
2011
Volume
412
Numéro
23-24
Pages
2070-5
Langue
anglais
Notes
Pieroni, Laurence
Delanaye, Pierre
Boutten, Anne
Bargnoux, Anne-Sophie
Rozet, Eric
Delatour, Vincent
Carlier, Marie-Christine
Hanser, Anne-Marie
Cavalier, Etienne
Froissart, Marc
Cristol, Jean-Paul
eng
Multicenter Study
Research Support, Non-U.S. Gov't
Netherlands
2011/08/02 06:00
Clin Chim Acta. 2011 Nov 20;412(23-24):2070-5. doi: 10.1016/j.cca.2011.07.012. Epub 2011 Jul 22.
Résumé
Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of those of serum creatinine assays. International recommendations highlight the need for traceable creatinine assays. The French Society of Clinical Biochemistry conducted a study for measuring accuracy of creatinine enzymatic methods. This evaluation involved 25 clinical laboratories. Creatinine was measured in serum pools ranging from 35.9+/-0.9 mumol/L to 174.5+/-3.1 mumol/L (IDMS determination) using 12 creatinine enzymatic methods. For all creatinine values greater than 74.4+/-1.4 mumol/L, the bias and imprecision did not exceed 5% and 5.9%, respectively. For the lowest value (35.9+/-0.9 mumol/L), the bias ranged from -1.8 to 9.9% (with one exception). At this level, the imprecision ranged from 1.9 to 7.8%. The true performances of the assays (couples of bias and relative standard deviation), were evaluated using Monte-Carlo simulations. Most of the assays fall within the maximum Total Error of 12% at all concentrations. This study demonstrates substantial improvements in the calibration, traceability and precision of the enzymatic methods, reaching the NKDEP recommendations. Moreover, most of these assays allowed accurate creatinine measurements for creatinine levels lower than 40 mumol/L.
Mots-clé
Calibration, Creatinine/*blood, Glomerular Filtration Rate, Humans, Monte Carlo Method, Reproducibility of Results
Pubmed
Création de la notice
03/03/2016 16:49
Dernière modification de la notice
20/08/2019 15:10
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