Amyotrophic lateral sclerosis: lessons in trial design from recent trials.

Détails

ID Serval
serval:BIB_A542DF77BDE3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Amyotrophic lateral sclerosis: lessons in trial design from recent trials.
Périodique
Journal of the Neurological Sciences
Auteur(s)
Borasio G.D.
ISSN
0022-510X (Print)
ISSN-L
0022-510X
Statut éditorial
Publié
Date de publication
1997
Volume
152
Numéro
Suppl. 1
Pages
S23-S28
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
The recent history of clinical trials in ALS is marked by a great diversity in trial design. This has limited the comparability of the trial results, and has resulted in intense discussions about which parameters should or should not be evaluated when testing a new drug for ALS. This article discusses, without any claim to completeness, some aspects of trial design in relation to past, ongoing and future ALS trials, including: choice of endpoints, measurement of disease progression, assessment of quality of life, placebo-controlled trials, open-label trials, collaboration with the industry, and methods for investigating mechanisms of action of experimental drugs.
Mots-clé
Amyotrophic Lateral Sclerosis/drug therapy, Amyotrophic Lateral Sclerosis/mortality, Clinical Trials as Topic/methods, Disease Progression, Humans, Research Design
Pubmed
Web of science
Création de la notice
14/01/2014 11:44
Dernière modification de la notice
20/08/2019 16:10
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