Amyotrophic lateral sclerosis: lessons in trial design from recent trials.

Details

Serval ID
serval:BIB_A542DF77BDE3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Amyotrophic lateral sclerosis: lessons in trial design from recent trials.
Journal
Journal of the Neurological Sciences
Author(s)
Borasio G.D.
ISSN
0022-510X (Print)
ISSN-L
0022-510X
Publication state
Published
Issued date
1997
Volume
152
Number
Suppl. 1
Pages
S23-S28
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
The recent history of clinical trials in ALS is marked by a great diversity in trial design. This has limited the comparability of the trial results, and has resulted in intense discussions about which parameters should or should not be evaluated when testing a new drug for ALS. This article discusses, without any claim to completeness, some aspects of trial design in relation to past, ongoing and future ALS trials, including: choice of endpoints, measurement of disease progression, assessment of quality of life, placebo-controlled trials, open-label trials, collaboration with the industry, and methods for investigating mechanisms of action of experimental drugs.
Keywords
Amyotrophic Lateral Sclerosis/drug therapy, Amyotrophic Lateral Sclerosis/mortality, Clinical Trials as Topic/methods, Disease Progression, Humans, Research Design
Pubmed
Web of science
Create date
14/01/2014 10:44
Last modification date
20/08/2019 15:10
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