Assessment of cerebral haemodynamic reserve: correlation between PET parameters and CO2 reactivity measured by the intravenous 133 xenon injection technique.

Détails

ID Serval
serval:BIB_A509971C3224
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessment of cerebral haemodynamic reserve: correlation between PET parameters and CO2 reactivity measured by the intravenous 133 xenon injection technique.
Périodique
Journal of Neurology, Neurosurgery, and Psychiatry
Auteur⸱e⸱s
Herold S., Brown M.M., Frackowiak R.S., Mansfield A.O., Thomas D.J., Marshall J.
ISSN
0022-3050 (Print)
ISSN-L
0022-3050
Statut éditorial
Publié
Date de publication
1988
Volume
51
Numéro
8
Pages
1045-1050
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Regional cerebral blood flow (CBF), oxygen utilisation, fractional oxygen extraction (OER) and cerebral blood volume (CBV) were measured by positron emission tomography (PET) in 21 patients with occlusive carotid artery disease. In the same patients, measurements of cerebral CO2 reactivity were performed using the intravenous xenon-133 technique. A significant correlation was found in symptomatic hemispheres between the CBF/CBV ratio and CO2 reactivity. Four patients had significant increases in OER and this was associated with a reduction in CBF/CBV ratio implying exhaustion of haemodynamic reserve. CO2 reactivity was reduced below 1.5% mm Hg in all four cases with raised OER but only in two cases with normal OER. In patients with CO2 reactivities above 1.5% mm Hg, OER was normal in all cases. It is concluded that measurements of CO2 reactivity provide a satisfactory method for assessing cerebral haemodynamic reserve.
Mots-clé
Aged, Blood Volume, Brain Ischemia/radionuclide imaging, Carbon Dioxide/diagnostic use, Carotid Artery Diseases/radionuclide imaging, Cerebrovascular Circulation, Hemodynamics, Homeostasis, Humans, Intracranial Arteriosclerosis/radionuclide imaging, Ischemic Attack, Transient/radionuclide imaging, Middle Aged, Oxygen Consumption, Tomography, Emission-Computed, Vasodilation, Xenon Radioisotopes/diagnostic use
Pubmed
Web of science
Création de la notice
08/10/2011 14:19
Dernière modification de la notice
20/08/2019 15:10
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