Assessment of cerebral haemodynamic reserve: correlation between PET parameters and CO2 reactivity measured by the intravenous 133 xenon injection technique.

Details

Serval ID
serval:BIB_A509971C3224
Type
Article: article from journal or magazin.
Collection
Publications
Title
Assessment of cerebral haemodynamic reserve: correlation between PET parameters and CO2 reactivity measured by the intravenous 133 xenon injection technique.
Journal
Journal of Neurology, Neurosurgery, and Psychiatry
Author(s)
Herold S., Brown M.M., Frackowiak R.S., Mansfield A.O., Thomas D.J., Marshall J.
ISSN
0022-3050 (Print)
ISSN-L
0022-3050
Publication state
Published
Issued date
1988
Volume
51
Number
8
Pages
1045-1050
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Regional cerebral blood flow (CBF), oxygen utilisation, fractional oxygen extraction (OER) and cerebral blood volume (CBV) were measured by positron emission tomography (PET) in 21 patients with occlusive carotid artery disease. In the same patients, measurements of cerebral CO2 reactivity were performed using the intravenous xenon-133 technique. A significant correlation was found in symptomatic hemispheres between the CBF/CBV ratio and CO2 reactivity. Four patients had significant increases in OER and this was associated with a reduction in CBF/CBV ratio implying exhaustion of haemodynamic reserve. CO2 reactivity was reduced below 1.5% mm Hg in all four cases with raised OER but only in two cases with normal OER. In patients with CO2 reactivities above 1.5% mm Hg, OER was normal in all cases. It is concluded that measurements of CO2 reactivity provide a satisfactory method for assessing cerebral haemodynamic reserve.
Keywords
Aged, Blood Volume, Brain Ischemia/radionuclide imaging, Carbon Dioxide/diagnostic use, Carotid Artery Diseases/radionuclide imaging, Cerebrovascular Circulation, Hemodynamics, Homeostasis, Humans, Intracranial Arteriosclerosis/radionuclide imaging, Ischemic Attack, Transient/radionuclide imaging, Middle Aged, Oxygen Consumption, Tomography, Emission-Computed, Vasodilation, Xenon Radioisotopes/diagnostic use
Pubmed
Web of science
Create date
08/10/2011 14:19
Last modification date
20/08/2019 15:10
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