Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death

Détails

ID Serval
serval:BIB_A4C6C5412169
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death
Périodique
Oncogene
Auteur(s)
Jarpe  M. B., Widmann  C., Knall  C., Schlesinger  T. K., Gibson  S., Yujiri  T., Fanger  G. R., Gelfand  E. W., Johnson  G. L.
ISSN
0950-9232 (Print)
Statut éditorial
Publié
Date de publication
09/1998
Volume
17
Numéro
11 Reviews
Pages
1475-82
Notes
Journal Article
Review --- Old month value: Sep 17
Résumé
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
Mots-clé
1-Phosphatidylinositol 3-Kinase/metabolism Animals Apoptosis/*physiology Caspases/metabolism Cytokines/metabolism Growth Substances/metabolism Humans MAP Kinase Kinase 3 *Mitogen-Activated Protein Kinase Kinases Protein-Serine-Threonine Kinases/metabolism Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins c-bcl-2/genetics/metabolism *Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:43
Dernière modification de la notice
20/08/2019 15:10
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