Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death
Details
Serval ID
serval:BIB_A4C6C5412169
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death
Journal
Oncogene
ISSN
0950-9232 (Print)
Publication state
Published
Issued date
09/1998
Volume
17
Number
11 Reviews
Pages
1475-82
Notes
Journal Article
Review --- Old month value: Sep 17
Review --- Old month value: Sep 17
Abstract
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
Keywords
1-Phosphatidylinositol 3-Kinase/metabolism
Animals
Apoptosis/*physiology
Caspases/metabolism
Cytokines/metabolism
Growth Substances/metabolism
Humans
MAP Kinase Kinase 3
*Mitogen-Activated Protein Kinase Kinases
Protein-Serine-Threonine Kinases/metabolism
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
*Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:43
Last modification date
20/08/2019 15:10
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