Acquired hemophilia as first manifestation of breast carcinoma in a man under long-term spironolactone therapy.

Détails

Ressource 1Télécharger: REF.pdf (309.65 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_A30146D0EE45
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Acquired hemophilia as first manifestation of breast carcinoma in a man under long-term spironolactone therapy.
Périodique
International Journal of Clinical Oncology / Japan Society of Clinical Oncology
Auteur⸱e⸱s
Lamy O., Elmiger H., Fiche M., Bauer J., Livio F.
ISSN
1341-9625
Statut éditorial
Publié
Date de publication
04/2004
Peer-reviewed
Oui
Volume
9
Numéro
2
Pages
130-133
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
A 69-year-old man under long-term spironolactone therapy (16 years) was hospitalized with spontaneous hematoma on the trunk and extremities. Coagulation studies disclosed an acquired hemophilia that was successfully treated with human factor VIII for a few days and immunosuppressive agents for several months. Physical examination revealed bilateral gynecomastia and an upper left quadrant breast nodule. Complete staging was unremarkable. Complete left mastectomy was performed. Histopathology showed invasive ductal carcinoma, expressing positivity for estrogen and progesterone receptors. The acquired hemophilia was considered to be a paraneoplasic syndrome. The question of a linkage between long-term spironolactone therapy and breast carcinoma is discussed.
Mots-clé
Aged, Antineoplastic Agents, Hormonal/therapeutic use, Biopsy, Needle/methods, Breast Neoplasms, Male/chemically induced, Breast Neoplasms, Male/diagnosis, Carcinoma, Ductal, Breast/chemically induced, Carcinoma, Ductal, Breast/diagnosis, Diuretics/adverse effects, Hemophilia A/etiology, Hemophilia A/therapy, Humans, Male, Mammography, Mastectomy/methods, Paraneoplastic Syndromes/etiology, Spironolactone/adverse effects, Tamoxifen/therapeutic use, Treatment Outcome
Pubmed
Open Access
Oui
Création de la notice
25/01/2008 13:55
Dernière modification de la notice
14/02/2022 7:56
Données d'usage