Acquired hemophilia as first manifestation of breast carcinoma in a man under long-term spironolactone therapy.

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State: Public
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Serval ID
serval:BIB_A30146D0EE45
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Acquired hemophilia as first manifestation of breast carcinoma in a man under long-term spironolactone therapy.
Journal
International Journal of Clinical Oncology / Japan Society of Clinical Oncology
Author(s)
Lamy O., Elmiger H., Fiche M., Bauer J., Livio F.
ISSN
1341-9625
Publication state
Published
Issued date
04/2004
Peer-reviewed
Oui
Volume
9
Number
2
Pages
130-133
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
A 69-year-old man under long-term spironolactone therapy (16 years) was hospitalized with spontaneous hematoma on the trunk and extremities. Coagulation studies disclosed an acquired hemophilia that was successfully treated with human factor VIII for a few days and immunosuppressive agents for several months. Physical examination revealed bilateral gynecomastia and an upper left quadrant breast nodule. Complete staging was unremarkable. Complete left mastectomy was performed. Histopathology showed invasive ductal carcinoma, expressing positivity for estrogen and progesterone receptors. The acquired hemophilia was considered to be a paraneoplasic syndrome. The question of a linkage between long-term spironolactone therapy and breast carcinoma is discussed.
Keywords
Aged, Antineoplastic Agents, Hormonal/therapeutic use, Biopsy, Needle/methods, Breast Neoplasms, Male/chemically induced, Breast Neoplasms, Male/diagnosis, Carcinoma, Ductal, Breast/chemically induced, Carcinoma, Ductal, Breast/diagnosis, Diuretics/adverse effects, Hemophilia A/etiology, Hemophilia A/therapy, Humans, Male, Mammography, Mastectomy/methods, Paraneoplastic Syndromes/etiology, Spironolactone/adverse effects, Tamoxifen/therapeutic use, Treatment Outcome
Pubmed
Open Access
Yes
Create date
25/01/2008 14:55
Last modification date
01/10/2019 7:19
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