Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
Détails
Télécharger: BIB_A277E25A9483.P001.pdf (1837.36 [Ko])
Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_A277E25A9483
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
Périodique
Nature Neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
16
Numéro
12
Pages
1728-1730
Langue
anglais
Notes
Toni N, Ming GL et Song H : Co-derniers auteurs (equal contribution) Publication types: Journal Article Publication Status: ppublish
Résumé
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
Pubmed
Web of science
Création de la notice
20/12/2013 10:48
Dernière modification de la notice
20/08/2019 15:08