Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
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Version: author
State: Public
Version: author
Serval ID
serval:BIB_A277E25A9483
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
Journal
Nature Neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
16
Number
12
Pages
1728-1730
Language
english
Notes
Toni N, Ming GL et Song H : Co-derniers auteurs (equal contribution) Publication types: Journal Article Publication Status: ppublish
Abstract
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
Pubmed
Web of science
Create date
20/12/2013 10:48
Last modification date
20/08/2019 15:08