A specific HPLC method for determination of beta-blockers topically used in ophthalmological diseases.
Détails
ID Serval
serval:BIB_9E2CAE5949A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A specific HPLC method for determination of beta-blockers topically used in ophthalmological diseases.
Périodique
Forensic Science International
ISSN
0379-0738[print], 0379-0738[linking]
Statut éditorial
Publié
Date de publication
1988
Volume
38
Numéro
1-2
Pages
37-41
Langue
anglais
Résumé
A HPLC method is presented for the identification and quantification in plasma and urine of beta-adrenergic receptor antagonists (betaxolol, carteolol, metipranolol, and timolol) commonly prescribed in ophthalmology. An extraction method is described using pindolol as an internal standard. An RSIL 10 micron column was used. The lower detection limits of the beta-blockers were found to be 4-27 ng/ml. This method is simple, rapid and sensitive; moreover, it allows the determination of 8 other beta-blockers.
Mots-clé
Administration, Topical, Adrenergic beta-Antagonists/administration & dosage, Adrenergic beta-Antagonists/analysis, Chromatography, High Pressure Liquid/methods, Eye Diseases/drug therapy, Humans, Pindolol/analysis, Reference Standards
Pubmed
Création de la notice
11/10/2010 15:15
Dernière modification de la notice
20/08/2019 16:04
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