A specific HPLC method for determination of beta-blockers topically used in ophthalmological diseases.

Details

Serval ID
serval:BIB_9E2CAE5949A8
Type
Article: article from journal or magazin.
Collection
Publications
Title
A specific HPLC method for determination of beta-blockers topically used in ophthalmological diseases.
Journal
Forensic Science International
Author(s)
Tracqui A., Kintz P., Himber J., Lugnier A.A., Mangin P.
ISSN
0379-0738[print], 0379-0738[linking]
Publication state
Published
Issued date
1988
Volume
38
Number
1-2
Pages
37-41
Language
english
Abstract
A HPLC method is presented for the identification and quantification in plasma and urine of beta-adrenergic receptor antagonists (betaxolol, carteolol, metipranolol, and timolol) commonly prescribed in ophthalmology. An extraction method is described using pindolol as an internal standard. An RSIL 10 micron column was used. The lower detection limits of the beta-blockers were found to be 4-27 ng/ml. This method is simple, rapid and sensitive; moreover, it allows the determination of 8 other beta-blockers.
Keywords
Administration, Topical, Adrenergic beta-Antagonists/administration & dosage, Adrenergic beta-Antagonists/analysis, Chromatography, High Pressure Liquid/methods, Eye Diseases/drug therapy, Humans, Pindolol/analysis, Reference Standards
Pubmed
Create date
11/10/2010 14:15
Last modification date
20/08/2019 15:04
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