Rituximab dans le traitement des maladies rénales glomérulaires: indications et evidences cliniques [Rationale and clinical evidence for the use of rituximab in glomerular diseases].

Détails

ID Serval
serval:BIB_9BB934CAAB4D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Rituximab dans le traitement des maladies rénales glomérulaires: indications et evidences cliniques [Rationale and clinical evidence for the use of rituximab in glomerular diseases].
Périodique
Revue Médicale Suisse
Auteur(s)
Mani L.Y., Vogt B., Burnier M., Golshayan D.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2011
Volume
7
Numéro
290
Pages
819-824
Langue
français
Résumé
Autoimmune glomerulopathies are an important cause of chronic kidney disease. Conventional treatments based on steroids, antiproliferative and cytotoxic agents are efficacious, but highly toxic. Because of their central role in the pathogenesis of autoimmunity, B cells have become an attractive therapeutic target. Rituximab is a monoclonal antibody directed against CD20 expressed on the surface of B cells, inducing profound depletion of B cells in the peripheral blood. In spite of encouraging results regarding the off-label use of Rituximab in membranous nephropathy, systemic lupus erythematosus and small vessel vasculitis, controlled, long-term data, and data with specific renal endpoints are currently lacking.
Mots-clé
Antibodies, Monoclonal, Murine-Derived/adverse effects, Antibodies, Monoclonal, Murine-Derived/pharmacology, Antigens, CD20/immunology, Autoimmune Diseases/drug therapy, Autoimmune Diseases/immunology, B-Lymphocytes/immunology, Chronic Disease, Humans, Immunologic Factors/adverse effects, Immunologic Factors/pharmacology, Kidney Diseases/drug therapy, Kidney Diseases/immunology, Kidney Glomerulus/drug effects, Kidney Glomerulus/pathology
Pubmed
Création de la notice
04/09/2011 15:05
Dernière modification de la notice
20/08/2019 15:02
Données d'usage