Rituximab dans le traitement des maladies rénales glomérulaires: indications et evidences cliniques [Rationale and clinical evidence for the use of rituximab in glomerular diseases].

Details

Serval ID
serval:BIB_9BB934CAAB4D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Rituximab dans le traitement des maladies rénales glomérulaires: indications et evidences cliniques [Rationale and clinical evidence for the use of rituximab in glomerular diseases].
Journal
Revue Médicale Suisse
Author(s)
Mani L.Y., Vogt B., Burnier M., Golshayan D.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2011
Volume
7
Number
290
Pages
819-824
Language
french
Abstract
Autoimmune glomerulopathies are an important cause of chronic kidney disease. Conventional treatments based on steroids, antiproliferative and cytotoxic agents are efficacious, but highly toxic. Because of their central role in the pathogenesis of autoimmunity, B cells have become an attractive therapeutic target. Rituximab is a monoclonal antibody directed against CD20 expressed on the surface of B cells, inducing profound depletion of B cells in the peripheral blood. In spite of encouraging results regarding the off-label use of Rituximab in membranous nephropathy, systemic lupus erythematosus and small vessel vasculitis, controlled, long-term data, and data with specific renal endpoints are currently lacking.
Keywords
Antibodies, Monoclonal, Murine-Derived/adverse effects, Antibodies, Monoclonal, Murine-Derived/pharmacology, Antigens, CD20/immunology, Autoimmune Diseases/drug therapy, Autoimmune Diseases/immunology, B-Lymphocytes/immunology, Chronic Disease, Humans, Immunologic Factors/adverse effects, Immunologic Factors/pharmacology, Kidney Diseases/drug therapy, Kidney Diseases/immunology, Kidney Glomerulus/drug effects, Kidney Glomerulus/pathology
Pubmed
Create date
04/09/2011 15:05
Last modification date
20/08/2019 15:02
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