Hydrogel nerve conduits produced from alginate/chitosan complexes
Détails
ID Serval
serval:BIB_9B4887AA88BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hydrogel nerve conduits produced from alginate/chitosan complexes
Périodique
Journal of Biomedical Materials Research. Part A
ISSN
1549-3296 (Print)
Statut éditorial
Publié
Date de publication
03/2007
Volume
80
Numéro
4
Pages
932-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Résumé
Nerve conduits (NCs) represent a promising alternative to conventional treatments for peripheral nerve repair. Materials for NC production should be biodegradable, possess adequate mechanical properties, and allow for exchange of nutrients. To this aim, we developed biodegradable NC made of a hydrogel that consisted of the oppositely charged polysaccharides alginate and chitosan. Swelling and permeation studies, as well as rheological measurements, served to characterize the NC. The alginate/chitosan NC showed high water uptake (84% w/w) and permitted permeation of fluorescent-labeled dextrans in a molecular weight dependent manner. The NC fulfilled the mechanical specifications without further crosslinking. The soft NC can be expected to preclude nerve compression (storage modulus of about 40 kPa), but possess sufficient mechanical strength. In combination with remarkable tear resistance, the NC affords easy surgical handling.
Mots-clé
*Absorbable Implants
Alginates/*chemistry
Chitosan/*chemistry
Glucuronic Acid/chemistry
Hexuronic Acids/chemistry
Hydrogels/*chemistry
Nerve Regeneration
Neural Conduction
Peripheral Nervous System Diseases/therapy
Pubmed
Web of science
Création de la notice
28/01/2008 9:22
Dernière modification de la notice
20/08/2019 16:02