Hydrogel nerve conduits produced from alginate/chitosan complexes

Details

Serval ID
serval:BIB_9B4887AA88BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hydrogel nerve conduits produced from alginate/chitosan complexes
Journal
Journal of Biomedical Materials Research. Part A
Author(s)
Pfister  L. A., Papaloizos  M., Merkle  H. P., Gander  B.
ISSN
1549-3296 (Print)
Publication state
Published
Issued date
03/2007
Volume
80
Number
4
Pages
932-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Abstract
Nerve conduits (NCs) represent a promising alternative to conventional treatments for peripheral nerve repair. Materials for NC production should be biodegradable, possess adequate mechanical properties, and allow for exchange of nutrients. To this aim, we developed biodegradable NC made of a hydrogel that consisted of the oppositely charged polysaccharides alginate and chitosan. Swelling and permeation studies, as well as rheological measurements, served to characterize the NC. The alginate/chitosan NC showed high water uptake (84% w/w) and permitted permeation of fluorescent-labeled dextrans in a molecular weight dependent manner. The NC fulfilled the mechanical specifications without further crosslinking. The soft NC can be expected to preclude nerve compression (storage modulus of about 40 kPa), but possess sufficient mechanical strength. In combination with remarkable tear resistance, the NC affords easy surgical handling.
Keywords
*Absorbable Implants Alginates/*chemistry Chitosan/*chemistry Glucuronic Acid/chemistry Hexuronic Acids/chemistry Hydrogels/*chemistry Nerve Regeneration Neural Conduction Peripheral Nervous System Diseases/therapy
Pubmed
Web of science
Create date
28/01/2008 8:22
Last modification date
20/08/2019 15:02
Usage data