B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.
Détails
ID Serval
serval:BIB_9A621E0CA32E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.
Périodique
Journal of Immunology
ISSN
0022-1767[print], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
162
Numéro
5
Pages
2538-2545
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV.
Mots-clé
Animals, Antigens, CD, Antigens, CD43, Antigens, CD45/analysis, B-Lymphocytes/immunology, Female, L-Selectin/analysis, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Retroviridae Infections/immunology, Retroviridae Infections/pathology, Sialoglycoproteins/analysis, Tumor Virus Infections/immunology, Tumor Virus Infections/pathology
Pubmed
Web of science
Création de la notice
24/01/2008 14:47
Dernière modification de la notice
20/08/2019 15:01