B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.

Details

Serval ID
serval:BIB_9A621E0CA32E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.
Journal
Journal of Immunology
Author(s)
Ardavín C., Martín P., Ferrero I., Azcoitia I., Anjuère F., Diggelmann H., Luthi F., Luther S., Acha-Orbea H.
ISSN
0022-1767[print], 0022-1767[linking]
Publication state
Published
Issued date
1999
Volume
162
Number
5
Pages
2538-2545
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV.
Keywords
Animals, Antigens, CD, Antigens, CD43, Antigens, CD45/analysis, B-Lymphocytes/immunology, Female, L-Selectin/analysis, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Retroviridae Infections/immunology, Retroviridae Infections/pathology, Sialoglycoproteins/analysis, Tumor Virus Infections/immunology, Tumor Virus Infections/pathology
Pubmed
Web of science
Create date
24/01/2008 14:47
Last modification date
20/08/2019 15:01
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